Molecular design, chemical synthesis, and evaluation of novel anthracene derivatives as a new family of protein photocleavers
نویسندگان
چکیده
The newly designed and synthesized artificial anthracene derivatives possessing a deoxyamino sugar effectively and randomly cleaved proteins, such as bovine serum albumin (BSA) and hen egg lysozyme (Lyso), during photoirradiation using a long wavelength UV light (365 nm) without any further additives. Furthermore, it was found that the cleaving ability of anthracene could be improved by the attachment of a suitable substituent into anthracene core skeleton. q 2006 Elsevier Ltd. All rights reserved.
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